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The Protein Folding Problem and Tertiary Structure Prediction

The Protein Folding Problem and Tertiary Structure Prediction Author : Kenneth M.Jr. Merz
Release : 2012-12-06
Publisher : Springer Science & Business Media
ISBN : 1468468316
File Size : 61.62 MB
Format : PDF
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A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.

Introduction to Computational Proteomics

Introduction to Computational Proteomics Author : Golan Yona
Release : 2010-12-09
Publisher : CRC Press
ISBN : 1000738272
File Size : 45.92 MB
Format : PDF, ePub
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Introduction to Computational Proteomics introduces the field of computational biology through a focused approach that tackles the different steps and problems involved with protein analysis, classification, and meta-organization. The book starts with the analysis of individual entities and works its way through the analysis of more complex entitie

Mathematics of Bioinformatics

Mathematics of Bioinformatics Author : Matthew He
Release : 2011-03-16
Publisher : John Wiley & Sons
ISBN : 9781118099520
File Size : 76.19 MB
Format : PDF, ePub, Docs
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Mathematics of Bioinformatics: Theory, Methods, andApplications provides a comprehensive format forconnecting and integrating information derived from mathematicalmethods and applying it to the understanding of biologicalsequences, structures, and networks. Each chapter is divided into anumber of sections based on the bioinformatics topics and relatedmathematical theory and methods. Each topic of the section iscomprised of the following three parts: an introduction to thebiological problems in bioinformatics; a presentationof relevant topics of mathematical theory and methods to thebioinformatics problems introduced in the first part; anintegrative overview that draws the connections and interfacesbetween bioinformatics problems/issues and mathematicaltheory/methods/applications.

Coarse-Grained Modeling of Biomolecules

Coarse-Grained Modeling of Biomolecules Author : Garegin A. Papoian
Release : 2017-10-30
Publisher : CRC Press
ISBN : 1315356708
File Size : 76.49 MB
Format : PDF, Mobi
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"The chapters in this book survey the progress in simulating biomolecular dynamics.... The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani." –from the Foreword by Peter G. Wolynes, Bullard-Welch Foundation Professor of Science, Rice University This book highlights the state-of-art in coarse-grained modeling of biomolecules, covering both fundamentals as well as various cutting edge applications. Coarse-graining of biomolecules is an area of rapid advances, with numerous new force fields having appeared recently and significant progress made in developing a systematic theory of coarse-graining. The contents start with first fundamental principles based on physics, then survey specific state-of-art coarse-grained force fields of proteins and nucleic acids, and provide examples of exciting biological problems that are at large scale, and hence, only amenable to coarse-grained modeling. Introduces coarse-grained models of proteins and nucleic acids. Showcases applications such as genome packaging in nuclei and understanding ribosome dynamics Gives the physical foundations of coarse-graining Demonstrates use of models for large-scale assemblies in modern studies Garegin A. Papoian is the first Monroe Martin Associate Professor with appointments in the Department of Chemistry and Biochemistry and the Institute for Physical Science and Technology at the University of Maryland.

Continuous Biopharmaceutical Processes

Continuous Biopharmaceutical Processes Author : David Pfister
Release : 2018-10-31
Publisher : Cambridge University Press
ISBN : 1108349781
File Size : 63.74 MB
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This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

Advanced Artificial Intelligence

Advanced Artificial Intelligence Author : Zhongzhi Shi
Release : 2011
Publisher : World Scientific
ISBN : 981429134X
File Size : 65.21 MB
Format : PDF, Docs
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'Advanced Artificial Intelligence' consists of 16 chapters. The content of the book is novel, reflects the research updates in this field, and especially summarises the author's scientific efforts over many years.

Functional Properties of Food Macromolecules

Functional Properties of Food Macromolecules Author : S.E. Hill
Release : 1998-08-31
Publisher : Springer Science & Business Media
ISBN : 9780751404210
File Size : 23.30 MB
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This edition updates the substantial progress that has occurred since 1988 in many aspects of understanding, measuring and utilizing functional macromolecules.

Monthly Index of Russian Accessions

Monthly Index of Russian Accessions Author :
Release : 1964
Publisher :
ISBN :
File Size : 47.55 MB
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Biochemistry and Cell Biology

Biochemistry and Cell Biology Author :
Release : 2006
Publisher :
ISBN :
File Size : 89.90 MB
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Mathematical Reviews

Mathematical Reviews Author :
Release : 2003
Publisher :
ISBN :
File Size : 78.54 MB
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Chemistry

Chemistry Author : Charles E. Mortimer
Release : 1986
Publisher :
ISBN :
File Size : 65.82 MB
Format : PDF, Docs
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Modeling of Creep for Structural Analysis

Modeling of Creep for Structural Analysis Author : Konstantin Naumenko
Release : 2007-04-06
Publisher : Springer Science & Business Media
ISBN : 3540708391
File Size : 21.55 MB
Format : PDF, ePub
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This book develops methods to simulate and analyze the time-dependent changes of stress and strain states in engineering structures up to the critical stage of creep rupture. The objective of this book is to review some of the classical and recently proposed approaches to the modeling of creep for structural analysis applications. It also aims to extend the collection of available solutions of creep problems by new, more sophisticated examples.